What Causes Blisters?

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In this video:

We’ve all seen them, and unfortunately most of us have had one. Those painful, pockets of goo that form because some over exercised, over caffeinated, happy to be living life, outdoors-man decides to include you in their daily torture fest that is a hike up mount agony! So what exactly is going on here that causes the formation of a blister?

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Sources:

http://publications.usa.gov/epublicat...
http://www.oandp.org/publications/jop...
http://medical-dictionary.thefreedict...
http://www.healthblurbs.com/ecthyma-b...
http://pharmaxchange.info/press/2011/...
http://chemweb.calpoly.edu/cbailey/37...