A Convergent Total Synthesis of (+)-Ineleganolide with Benjamin Gross

In this Research Spotlight episode hosted by our Synthesis Workshop Editorial Board member Kathleen Cheasty, Benjamin Gross shares his work on the total synthesis of (+)-ineleganolide from the Stoltz group at Caltech.

Key reference:
J. Am. Chem. Soc. 2023, 145, 7763–7767.
https://doi.org/10.1021/jacs.3c02142

Additional references (in order of appearance):
For isolation report see: Tetrahedron Lett. 1999, 40, 6033−6035. Image attribution: George Berninger Jr., CC BY-SA 3.0, https://creativecommons.org/licenses/..., via Wikimedia Commons.
(a) Tetrahedron 2011, 67, 10045−10052. (b) J. Am. Chem. Soc. 2022, 144, 20539−20547.
Chem. Sci. 2017, 8, 507−514. For computational work see: Tetrahedron 2021, 93, 132289.
J. Org. Chem. 2016, 81, 1819−1838.
Science 2016, 352, 1078−1082; J. Am. Chem. Soc. 2022, 144, 20232−20236.
Chem. Sci. 2017, 8, 507−514.
R. Soc. Open Sci. 2018, 5, 171988.