Isotope Days 2024-NMR with Adam Sutton, PhD

Quantitative Benchtop NMR for Vaccine Development

Dr. Adam Sutton from Merck Research Labs discusses the application of benchtop NMR in the vaccine development process. He highlights the complexity and diversity of vaccine formulations and the need for versatile analytical tools. Benchtop NMR is presented as a convenient, green, and cost-effective alternative to traditional chromatography methods for the quantification of small molecule excipients and reaction intermediates. Dr. Sutton emphasizes the simplicity and ease of use of benchtop NMR, allowing non-expert users to quickly analyze samples with minimal preparation. He shares several examples of benchtop NMR applications in vaccine development, including the quantification of histidine and polysorbate in complex vaccine intermediates, monitoring of ethanol in liposomal and lipid nanoparticle formulations, and online tracking of deprotection reactions. Dr. Sutton concludes by highlighting the advantages of benchtop NMR, including its convenience, accuracy, precision, and versatility, as well as its limitations, such as low sensitivity and signal overlap challenges.

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