Скачать или смотреть TIGHT JUNCTION //CELLULAR JUNCTION//CELL CELL INTERACTION.

Tight junctions (also called zonula occludens) are specialized connections between adjacent epithelial cells that create a seal to prevent leakage of molecules through the space between the cells (paracellular pathway).

They are mainly located at the apical region of epithelial cells and play a crucial role in:

Maintaining cell polarity by preventing the mixing of membrane proteins between apical and basolateral surfaces.

Forming a selective barrier to control the movement of substances.


Main Proteins Involved:

Claudins

Occludin

Junctional Adhesion Molecules (JAMs)

ZO proteins (e.g., ZO-1, ZO-2)


Example Tissues:

Intestinal epithelium

Blood-brain barrier

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