Скачать или смотреть निरोगी भ्रूण से स्वस्थ बच्चा कैसे प्राप्त करें। ( pre-impantn genetic test. PGT-A, PGT-M, PGT-SR)

Pre-implantation Genetic Testing (PGT)

Definition:
PGT is a technique used in assisted reproductive technology (ART), particularly IVF, to test embryos for genetic abnormalities before transfer to the uterus.

Types:

PGT-A (Aneuploidy): Detects chromosomal abnormalities (extra or missing chromosomes).

PGT-M (Monogenic disorders): Screens for single-gene mutations (e.g., thalassemia, cystic fibrosis).

PGT-SR (Structural rearrangements): Identifies chromosomal translocations or inversions.

Procedure:

Ovarian stimulation → IVF/ICSI → embryo culture → biopsy of polar body, blastomere, or trophectoderm cells → genetic testing (NGS, PCR, FISH, aCGH) → transfer of healthy embryo.

Indications:

Advanced maternal age.

Recurrent implantation failure or miscarriage.

Carriers of genetic diseases or chromosomal rearrangements.

Severe male factor infertility.

Advantages:

Reduces risk of genetic disease transmission.

Improves implantation and pregnancy rates.

Reduces miscarriage risk.

Limitations:

Invasive to embryo.

Costly, technically demanding.

May not detect all genetic abnormalities.

👉 In short: PGT is a valuable tool in IVF to select genetically normal embryos, improving outcomes and reducing the risk of inherited disorders.