Скачать или смотреть Mycobacteria, Advanced Microscopy, & Cell Metabolism - The Rego Lab at Yale School of Medicine

For more information on Hesper Rego or #YaleSchoolOfMedicine, visit: https://medicine.yale.edu/profile/hes... and https://campuspress.yale.edu/regolab.

The Rego Lab is interested in the cells at the edges of the distribution. The ones that do not look like the others, often labeled as ‘weird’, and overlooked in most conventional approaches that only consider the behavior of the average cell. Their underlying hypothesis is that a lot of biology exists at the edges, and sometimes, the most interesting cells exist far away from the population average. We apply this thinking to pathogenesis, in which there are clear examples of rare subpopulations playing important roles. They study mycobacteria. The most famous mycobacteria, Mycobacterium tuberculosis, causes tuberculosis, the world’s deadliest infectious disease. Part of the reason for M. tuberculosis’s success as a pathogen is that it can exhibit a tremendous amount of variability even in a genetically identical population. This diversity allows the pathogen to survive the stresses imposed by the host and by the antibiotics used to treat the disease. The Rego Lab uses various techniques – from parallel transposon sequencing to super-resolution microscopy – to discover the strategies mycobacteria use to grow and survive. The hope is that what they learn will be helpful in designing new tuberculosis therapeutics designed to kill the infection faster and more completely.

0:00 The Rego Lab
0:29 What are they studying?
1:55 How are they studying it?
2:57 Where might this research lead?