Скачать или смотреть Left Ventricle Remodelling During Heart Failure

Left ventricle remodeling during heart failure refers to the changes in the structure and function of the left ventricle (LV) in response to injury, disease, or increased workload. These changes can be adaptive or maladaptive, leading to:

Adaptive remodeling:

1. Hypertrophy (thickening) of the LV wall
2. Increased contractility
3. Improved cardiac output

Maladaptive remodeling:

1. Dilatation (enlargement) of the LV chamber
2. Thinness of the LV wall
3. Decreased contractility
4. Fibrosis (scarring)
5. Apoptosis (cell death)

Types of LV remodeling:

1. Concentric remodeling (thickening without dilatation)
2. Eccentric remodeling (dilatation without thickening)
3. Mixed remodeling (both thickening and dilatation)

Causes of LV remodeling:

1. Myocardial infarction (heart attack)
2. Hypertension
3. Valve disease
4. Cardiomyopathy
5. Heart failure

Consequences of LV remodeling:

1. Decreased cardiac function
2. Increased risk of arrhythmias
3. Worsening heart failure symptoms
4. Poorer prognosis

Treatment strategies:

1. Pharmacological therapy (e.g., ACE inhibitors, beta-blockers)
2. Device therapy (e.g., pacemakers, ICDs)
3. Surgical intervention (e.g., heart transplantation)
4. Lifestyle modifications (e.g., exercise, diet)

#Heartfailure