Скачать или смотреть ERRP Chromatography: Revolutionizing Peptide Separations

In this video, we explore the groundbreaking work of Giulia Mazzoccanti and her team at Sapienza University of Rome. They've developed a powerful technique called Electrostatic Repulsion-Reversed Phase (ERRP) chromatography, which has revolutionized peptide separations.
ERRP combines conventional reversed-phase retention with controlled electrostatic repulsion, resulting in improved selectivity, peak symmetry, and resolution. This technique has advanced from small basic compounds to complex glucagon-like peptide-1 (GLP-1) analogues, enabling the separation of epimeric and process-related impurities that are indistinguishable by spectrometry alone.
We delve into the details of ERRP, its modes (static and dynamic), and its applications in separating native and modified forms of GLP-1 analogues. Learn how ERRP addresses the challenges of characterizing epimeric impurities and its potential for analyzing peptide therapeutics.
Join us as we uncover the versatility and impact of ERRP chromatography in the field of peptide analysis.