Скачать или смотреть The Importance of Reproducible Research in High-Throughput Biology

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Speaker: Keith A. Baggerly, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston

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0:00 The Importance of Reproducibility in High-Throughput Biology: Case Studies in Forensic Bioinformatics
1:19 Why is RR So Important in H-TB?
2:43 Using the NCI60 to Predict Sensitivity
5:19 Fit Training Data
5:58 Fit Testing Data
6:46 5-FU Heatmaps - 1
7:21 5-FU Heatmaps - 2
7:30 5-FU Heatmaps - 3
7:46 Their List and Ours
8:28 Offset P-Values: Other Drugs
9:02 Using Their Software
10:00 Heatmaps Match Exactly for Most Drugs! - 1
10:45 Heatmaps Match Exactly for Most Drugs! - 2
11:34 Predicting Docetaxel (Chang 03)
12:36 Predicting Adriamycin (Holleman 04)
13:51 There Were Other Genes...
15:12 RR Theme: Don't Take My Word For It!
15:45 Potti/Nevins Reply (Nat Med 13:1277-8)
16:51 Adriamycin 0.9999 + Correlations (Reply) - 1
17:54 Adriamycin 0.9999 + Correlations (Reply) - 2
18:22 The First 20 Files Now Named
19:14 Validation 1: Hsu et al
20:29 The 4 We Can't Match (Reply)
21:00 Some Timeline Here... - 1
21:12 Some Timeline Here... - 2
21:44 Some Timeline Here... - 3
22:00 Jan 29, 2010
22:21 Why We're Unhappy... - 1
22:44 Why We're Unhappy... - 2
23:25 We Tried Matching The Samples
24:36 FOI(L)A! - 1
24:54 FOI(L)A! - 2
25:32 May 14, 2010
25:53 July 16, 2010
26:21 July 19, 2010
26:48 Subsequent Events, and a Caveat - 1
27:13 Subsequent Events, and a Caveat - 2
27:30 Some Observations
28:09 What Should the Norm Be?
28:38 Some Lessons
29:42 Questions