Скачать или смотреть Glycogenolysis Regulation. How Glycogen is Broken Down. cAMP & Ca2+/Calmodulin Pathways.

This lecture starts by defining glycogenolysis and glycolysis and discussing the basic relationship between the two. It then discusses why skeletal muscle cells want to increase the rate of glycogenolysis during exercise. Next it explains the function of glycogen phosphorylase and how it is regulated by cAMP and calcium/calmodulin pathways. It then explains how epinephrine activates a cAMP pathway and how the pathway increases the activity of glycogen phosphorylase. It finishes by explaining the calcium/calmodulin pathway and how it activates glycogen phosphorylase.

0:00 Defining Glycogenolysis and Glycolysis
4:12 Exercise and Glycogenolysis
9:35 Function and Regulation of Glycogen Phosphorylase
12:38 Epinephrine and cAMP Pathway
20:27 PKA & Glycogen Phosphorylase Activation
22:31 Calcium/Calmodulin & Glycogen Phosphorylase Activation
27:47 Summary