Pediatric Low Grade Glioma

Low-grade gliomas can present in various ways, including vomiting, headaches and neurologic changes. While there are different types of low-grade gliomas, such as pleomorphic xanthoastrocytoma, pilomyxoid astrocytoma or ganglioglioma, they all fall into a single pathway of disease.

In this video, pediatric neuro-oncologist Jean Mulcahy-Levy, MD, explains the disease pathway, which starts with the RAS regulator protein and signals to other proteins, including BRAF, MEK and ERK. A loss of RAS regulation may result in unregulated cell growth, leading to low grade gliomas. Dr. Mulcahy-Levy also discusses various treatment options, including surgery, chemotherapy, targeted therapy (e.g., BRAF and MEK inhibitors) and radiation. For parents of a child with a low-grade glioma, Dr. Mulcahy-Levy provides suggestions for parent resources and support groups.

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