Скачать или смотреть Advances in CAR T-cell therapy - Dr. Bhagirathbhai Delaria (Vanderbilt University)

Dr. Bhagirathbhai Delaria, an associate professor at Vanderbilt Medical Center, presented on cellular immunotherapy and stem cell transplantation, focusing on CAR T-cell therapy. He discussed the evolution of CAR T-cell therapy from autologous stem cell transplants, highlighting its effectiveness in treating relapsed/refractory lymphoma and multiple myeloma. Dr. Delaria explained the manufacturing process, clinical trials, and the shift toward earlier treatment with CAR T-cells. He addressed side effects, including cytokine release syndrome and neurological toxicity, and discussed ongoing research to improve safety and efficacy. The presentation also covered the high cost of CAR T-therapy in the U.S. compared to other countries and potential future developments, such as decentralized manufacturing and in vivo CAR T-cells.