Скачать или смотреть A Dual-Purpose ncAA for the Expanded Genetic Code: Combining Metal-Binding and Click Chemistry

Talk given by Amanda Jarvis (Univ of Edinburgh, UK) as part of the International GCE Webinar series. Live talk given on February 20th, 2025.

Genetic code expansion has drastically increased the number of amino acids we can incorporate into protein scaffolds, including expanding the range of metal-binding amino acids. Unnatural amino acids containing rigid bidentate ligands as side chains, such as bipyridylalanine, offer different structural binding motifs to the canonical amino acids. This allows the possibility of building up very different metal active sites to those found in natural metalloproteins, enabling new-to-nature chemistry to be introduced to the biological toolbox. In this talk I will showcase our group’s work using metal-binding unnatural amino acids including a novel pyridyl-triazine amino acid.