Embryonic Development of the Islets of Langerhans | Science Animation | Medical Animation

The Islets of Langerhans are an important part of the human endocrine system, and understanding their formation is important for gaining insights into combating diseases such as diabetes.

These structures are formed from an initial cord, from which cells that express neurogenin-3 emerge and form buds. The cells in these buds differentiate to form the mature islet, which then becomes vascularized, providing the blood with various hormones, including insulin.

Nadav Sharon of the Doug Melton group at the Harvard Stem Cell Institute approached us to visualize his research. In the process of creating the animation above, we developed a numerical model to emulate the behavior of the cells involved. The model to drive the animation proved very insightful and led to Sharon going back in the lab to validate our model. This in the end led to a contribution on our part to his publication in Cell.

With Luke Whitehorn credited as co-author for the work he completed on this project. Typically, we are not part of the actual research but only help to communicate concepts and results. However, the project is a great example of how we develop tools and methods to visualize nature, as it has never been shown before, and we take great pride in this accolade.

#science #medicalanimation #diabetes

CONTENT
00:00 The Islets of Langerhans
00:23 Type 1 Diabetes
00:55 Peninsula Formation
01:50 Alpha Cells Formation
02:02 Beta Cells Formation
02:17 Delta Cells Formation
02:52 Vascularization of the Islets

SOURCE
Melton Laboratory, Harvard University
https://www.cell.com/cell/fulltext/S0...

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