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Trp operon Attenuation | regulation of Trp operon | CSIR-NET | NEET | B.Sc.| M.Sc.

Understanding TRP Operon Attenuation: A Key Mechanism in Gene Regulation 🧬🔬

The TRP operon attenuation mechanism is a fascinating example of gene regulation in prokaryotes, particularly in E. coli. This process allows cells to finely control the synthesis of tryptophan, an essential amino acid, based on its availability. When tryptophan levels are high, the ribosome quickly translates the leader sequence, causing the formation of a terminator loop in the mRNA. This loop halts transcription, preventing the expression of tryptophan biosynthetic genes. Conversely, when tryptophan is scarce, the ribosome stalls, allowing the formation of an anti-terminator loop, and transcription proceeds. This elegant feedback system ensures that cells maintain metabolic balance efficiently.

Explore how this intricate regulatory mechanism helps bacteria adapt to environmental changes and maintains homeostasis.

Timestamps:
00:00 Intro to Transcription & Translation Coupling 🧬
00:54 Understanding the Tryptophan Operon 🎤
01:30 Leader Region Structure: A Closer Look 🔍
02:47 Signals from RNA Pairing: Pause & Termination ⚠️
03:10 Role of Codons in the Leader Region 📏
04:03 Importance of Coupled Transcription & Translation 🔗
07:10 Translation Mediated Transcription Termination 🛑
09:58 Tryptophan Abundance and its Impact on Translation 💡

If you missed the lesson 1, here is the link:

Lesson 1:    • Tryptophan operon | Easiest explanation | ...  


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Gene Expression
Prokaryotic Regulation
Tryptophan Synthesis
Ribosome Stalling
Genetic Feedback
Metabolic Control
Bacterial Genetics
Gene Control Mechanism
Cellular Adaptation
Gene regulation in prokaryotes
Attenuation of Trp operon
Regulation of Trp operon
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