Developing Reproducible Small Animal Models to Better Reflect Lung Fibrosis Pathophysiology

In a recent webinar titled “Developing Reproducible Small Animal Models to Better Reflect Lung Fibrosis Pathophysiology”, Dr. Elizabeth Redente shared insights for the study of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases using murine models. Her focus centered on expanding the use and relevance of the single-dose bleomycin model to models of persistent fibrotic disease using genetics, age, sex and repetitive injury. Additionally, Dr. Redente discussed the occupational model of silicosis. Integrated into the model discussion are analytical methods to examine pathophysiology outcomes including pathology, lung physiology using flexiVent, microCT analysis and oxygen saturation. Lastly, Dr. Redente explored different methods of therapeutic intervention and targeted loss of fibroblast populations.

Key topics include:

Multiple variables that contribute to successful animal models of fibrosis, including genetics, age, sex, repetitive injury and occupational exposure
An overview of pathophysiology with increased overlap to patient pulmonary fibrosis
An overview of clinically relevant outcomes during persistent fibrosis inducing flexiVent, small animal microCT and pulse oximetry
Using persistent fibrosis models for therapeutic intervention.