Low and Ultra-Low Doses of Cannabinoids: Are We Missing the Sweet Spot? - Dustin Sulak, DO

Tags: Stress, Hormesis, Dosing, Endocannabinoid System, THC, CBDA, Inflammation, Dose Response, Medicine

Dustin Sulak, DO, presents "Low and Ultra-Low Doses of Cannabinoids: Are We Missing the Sweet Spot?" at CannMed 23.

0:00 Intro
2:07 Overview
2:51 THC Overdose: Paradoxical Effects
3:57 Cannabis Dosing: Wide Range
5:07 Biphasic Dose-Response
5:32 Multiphasic Dose-Response
7:42 Hormesis
9:32 Exercise: ECS Responds to Stress
11:28 Pre-Conditioning Hormesis
12:31 Homeopathy: Post-Conditioning Hormesis
13:08 How Cannabis Works
13:25 Ultra-Low Dose Orientation
20:23 Methods
20:35 Results
21:58 Low and Ultra-Low Dose Mechanisms
26:21 Ultra-Potent Trace Cannabinoids
26:45 Recommendations
31:18 Q&A

Compared to other medications, cannabis and its constituents have an unusually broad range of safe and effective doses known to produce clinical results. Preclinical and clinical evidence suggests powerful physiological effects can be produced with low and ultra-low doses of cannabis.

Therapeutic effects of cannabis and its constituents may be possible with doses much lower than those commonly used in clinical practice, but many unknowns still exist. Clinicians and researchers may benefit by exploring dose-response trends in the low and ultra-low dose ranges.

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