Revolutionizing Brain Health: Genetics, Lipid Science, and Cutting-Edge Dementia Prevention

What does cholesterol have to do with dementia? Join me in Episode #333 as I sit down with Dr Kellyann Niotis and Dr Thomas Dayspring to explore how cholesterol metabolism impacts brain health and what you can do to reduce your risk of cognitive decline. From cutting-edge insights into cholesterol’s role in neurodegenerative diseases to key risk factors for dementia, this episode provides practical tips to help you protect your brain for years to come.

👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/

Dr Kellyann Niotis is a preventive neurologist and the Director of Parkinson’s Disease & Lewy Body Dementia Prevention Research at the Institute for Neurodegenerative Diseases Florida. She leads the preventive neurology program at Early Medical and is the first fellowship-trained preventive neurologist in the U.S. Dr Thomas Dayspring is a renowned clinical lipidologist, Fellow of the American College of Physicians, and expert in cholesterol metabolism with decades of experience. Together, they bring extensive knowledge and understanding of how cholesterol and lifestyle factors impact brain and cardiovascular health.

Connect with Dr Kellyann Niotis:
Website: https://drkellyannniotis.com/
Resources and research: https://ind.org/

Connect with Dr Thomas Dayspring:
Twitter/X: https://x.com/Drlipid
LinkedIn:   / thomas-dayspring-md-facp-fnla-3aaa876  
Past episodes: https://theproof.com/tag/thomas-daysp...

Highlights:
00:00 Intro
07:53 Cardiology Meets Neurology: Understanding the Connection
13:26 Dementia and Neurodegenerative Diseases: A Comprehensive Overview
21:36 Recognizing Early Dementia Signs and Risk Factors
32:36 Lipoproteins and Brain Health: The Crucial Link
44:20 ApoB vs ApoE: Comparing Apoprotein Functions in Neurological Health
01:01:13 APOE4 Carriers: Potential Therapeutic Approaches
01:04:10 ApoA1 and HDL: Their Role in Dementia Prevention
01:14:15 Genetic Testing for Dementia: Understanding APOE4 Implications
01:19:51 APOE4 Gene: Impact on Dementia Risk and Brain Health
01:22:53 Desmosterol's Role in Maintaining Brain Health
01:36:25 LDL Cholesterol: A Key Factor in Dementia Risk Assessment
01:43:27 APOE4: Comparing Single vs. Double Copy Risk Factors
01:48:13 Omega-3 Fatty Acids: Essential Nutrients for Brain Health
01:58:43 LDL Cholesterol Levels: Assessing Low vs. High Risk for Dementia
02:01:57 Key Takeaways: Preventive Neurology and Future Research Directions

If you have any additional questions you would like answered in the future, let me know in the comments.

Enjoy, friends.
Simon

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Simon Hill, MSc, BSc (Hons)

Creator of http://theproof.com/ and host of https://theproof.com/podcast/

Author of https://theproof.com/book/

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