Vitiligo - Pathophysiology

#vitíligo #vitiligoskin #vitiligolife #vitiligoislife #pigmentation
#melanin #skincolor #darkskin #lightskin

Introduction - 03:33
Intrinsic abnormalities in Vitiligo - 11:21
A. Autoimmune Hypothesis - 16:03
A. Autoimmune Hypothesis: Resident Memory T-Cells - 27:26
B. Oxidative Stress - 30:17
B. Oxidative Stress: Protective Machinery - 32:17
B. Oxidative Stress: T-Cell Activation - 34:00
B. Oxidative Stress: Oxidant-Antioxidant Balance - 35:46
B. Oxidative Stress: Unfolded Protein Response [UPR] - 39:10
B. Oxidative Stress: Exosomes Signalling - 41:43
B. Oxidative Stress: Mechanisms - 43:10
C. Cell Adhesion Defects: Melanocytorrhagy - 45:36
D. Neural Theory - 48:09
E. Somatic Cutaneous Mosaicism Theory - 50:54
Vitiligo Pathogenesis: Recap - 53:53
Further Reading - 57:38
End - 58:52

Further Reading:

1. Chapter 76 – Vitiligo. In: Fitzpatrick’s Dermatology, 9ed. Pg-1330, Ezzedine K et al.

2. Chapter 66 – Vitiligo and other disorders of hypopigmentation. In: Bolognia’s Dermatology, 4ed. Pg-1087, Passeron T et al.

3. Seneschal J, Boniface K, D'Arino A, Picardo M. An update on Vitiligo pathogenesis. Pigment Cell Melanoma Res. 2021 Mar;34(2):236-243.

4. Chang WL, Ko CH. The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications. Cells. 2023 Mar 19;12(6):936.

5. Xie Y, Wu N, Tang S, Zhou Z, Chen J, Li J, Wu F, Xu M, Xu X, Liu Y, Ma X. Endoplasmic Reticulum Dysfunction: An Emerging Mechanism of Vitiligo Pathogenesis. Clin Cosmet Investig Dermatol. 2024 May 17;17:1133-1144.

6. Frisoli ML, Essien K, Harris JE. Vitiligo: Mechanisms of Pathogenesis and Treatment. Annu Rev Immunol. 2020 Apr 26;38:621-648.

7. Chapter 86 – Acquired Pigmentary Disorders. In: Rooks Textbook of Dermatology, 10ed. Pg-86.1, Geel NV et al.