New Study: Hormone Therapy & Heart Disease | Diet & Exercise | Mark Scholz, MD | PCRI

Weight Training Protocol: https://pcri.org/sky-2/2017/9/19/fitn...
Androgen-deprivation therapy and risk of death from cardio-vascular disease in prostate cancer patients: a nationwide lithuanian population-based cohort study: https://www.tandfonline.com/doi/full/...

Hormone therapy (that is, reducing a man's testosterone to near zero) is one of the most daunting parts of prostate cancer treatment for men, and a new study has demonstrated that men on hormone therapy have a higher incidence of heart disease and diabetes. However, hormone therapy can be essential in cases of advanced disease to prevent prostate cancer mortality, and it is also useful for improving cure rates in men with intermediate- to high-risk prostate cancer that is assumed to be at least mostly localized. Moreover, while the side effects of hormone therapy can be profound, they are usually temporary if they are well-managed, which makes it an attractive option when compared to other modalities with risks of permanent side effects. Here, Dr. Scholz explains that the increased risks of diabetes and cardiovascular disease from hormone therapy are largely related to the accelerated weight gain and muscle loss that oftentimes occurs if a man does not change his habits to compensate for his reduced testosterone (especially diet and exercise with emphasis on resistance training). He also provides strategies for mitigating the rest of the long list of side effects that come when a man's testosterone is suddenly reduced to negligible.

0:09 Recently, there was a study involving 13,000 men that found increased cardiovascular risks with men on hormone therapy versus men without hormone therapy. Can you explain?

3:48 The study found that the cardiovascular risks from hormone therapy is highest in older men. How should older patients manage this risk?

5:32 Does the cardiovascular risks from hormone therapy go away once the hormone therapy has stopped?

6:28 To what extent does hormone therapy affect memory?

7:44 How do you weigh the risks and benefits of hormone therapy?

9:20 What are some tips for men to mitigate the side effects of hormone therapy?

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