Calcifying Odontogenic Cyst (COC)

Calcifying odontogenic cyst (COC) was first described by Gorlin in 1962.
It is a cystic lesion characterized histologically by the presence of an ameloblastomatous epithelial lining and ghost cells.

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References and further reading:
💡Speight PM, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018 Mar;472(3):331-339.
💡Barnes L, Eveson JW, Reichart P, Sidransky D (2005) Odontogenic Tumours. Ch 6, WHO classification of tumors: pathology and genetics of head and neck tumours. IARC, Lyon.
💡Kramer I, Pindborg J, Shear M (1992) WHO International Histological Classification of Tumours. Histological typing of odontogenic tumours, 2nd edn. Springer-Verlag, Berlin.
💡Tomich CE. Calcifying odontogenic cyst and dentinogenic ghost cell tumor. Oral Maxillofac Surg Clin North Am. 2004 Aug;16(3):391-7.
💡Reichart PA, Philipsen HP. Odontogenic tumors and allied lesions. Quintessence Publishing; 2004
💡Shear M, Speight PM. Cysts of the Oral and Maxillofacial Regions. 4 th ed. Blackwell Munksgaard; 2007.
💡Neville BW, Damm DD, Allen CM, Chi A. Oral and Maxillofacial Pathology. South Asian ed. Elsevier; 2016.
💡Rajendran R, Sivapathasundaram B. Shafer’s Textbook of Oral Pathology. 7th ed. Elsevier; 2012.
💡Regezzi JA, Sciubba JJ, Jordan RCK. Oral Pathology: Clinical Pathologic Correlations. 5 th ed. Elsevier; 2007.

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