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Effects of filtered bone marrow-derived stem cell lysate on neurogenic bladder

Shibayama M1, Hotta Y1, Matsumoto S2, Maeda K1, Yamamoto T3, Kimura K4

1. Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan, 2. Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan/Clinical Research Support Center, Asahikawa Medical University Hospital, Asahikawa, Japan, 3. Clinical Research Support Center, Asahikawa Medical University Hospital, Asahikawa, Japan/Laboratory for Clinical Application of Adipose-Derived Regenerative Cells, Nagoya University Graduate School of Medicine, Nagoya, Japan, 4. Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan/Department of Clinical Pharmaceutics, Nagoya City University, Graduate School of Medical Sciences and Medical Sciences, Japan

KEYWORDS: Animal Study, Stem Cells / Tissue Engineering, Pharmacology, Incontinence, Underactive Bladder

Lower urinary tract dysfunction (LUTD) occurs as a complication of pelvic surgery. Pelvic nerve injury is known to cause LUTD such as an underactive bladder; however, the consequences of hypogastric nerve injury remain unknown. On the other hand, a recent review reported that stem cell transplantation is effective in the treatment of LUTD. [1] However, there are many hurdles in stem cell therapy such as complicated handling of cells, high risk of immune response, and high cost, among others. In addition, many reports have suggested that the improvements following stem cell therapy are due to the paracrine effects such as growth factors or cytokines from the cells, and not the differentiation ability of the stem cells.[1] We focused on the contents of stem cells, which have the potential to solve these problems. In this study, we investigated the effectiveness of filtered bone marrow-derived stem cell lysate (FBMSCL) in a model of overflow urinary incontinence caused by bilateral hypogastric nerve injury.

Read the full abstract text here: https://www.ics.org/2020/abstract/456