Tackling MedChem Bias One Functional Group at a Time

As medicinal chemists, we all have biases when looking at molecules and even just at functional groups. We occasionally encounter functional groups in drug candidates that are far from typical. Some groups may seem unusual at first glance, raising questions about their previous use and the specific impact they have on a compound's properties.

In this Flash Talk, Gilles Ouvry, explores four functional groups that have not been in the mainstream of medicinal chemistry.

00:00 Welcome and introduction
7:15 Intro to new substructure search functionality
09:02 Presentation
9:46 Oxamides
18:00 Hydroxamic Esters
28:37 Phosphonates and Phosphorus-Containing Groups
37:00 Aliphatic Chlorides
43:35 Q&A

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Presented by Gilles Ouvry, Ph.D. with host Dennis Koester, Ph.D. Director of Industry Research and Relations, Drug Hunter

Recorded on September 19, 2024, as a Drug Hunter Flash Talk.

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