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2025 American Society of Hematology Expert Insights: New Approach to CALR-Mutant Myelofibrosis

This conversation features Gabriela Hobbs, MD (Massachusetts General Hospital), and Aaron Gerds, MD (Editor-in-Chief of ASH Clinical News), discussing early clinical insights on a targeted antibody therapy for mutant CALR in myelofibrosis.

This video serves as one installment in a multi-part series of expert conversations and study highlights from the 2025 American Society of Hematology (ASH) Annual Meeting.

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🎤 Speaker: Gabriela Hobbs, MD, Massachusetts General Hospital
🎤 Interviewer: Aaron Gerds, MD, Editor-in-Chief, ASH Clinical News

The discussion centers on first-in-human findings for an investigational antibody designed to selectively target mutant calreticulin in patients with myelofibrosis. Early-phase results suggest the therapy was generally well tolerated, both on its own and in combination with ruxolitinib, in patients with limited treatment options.

📖🔗 Read the full article: “Early Data Show Mutant CALR-Specific Monoclonal Antibody Well Tolerated in Myelofibrosis” https://ashpublications.org/ashclinic...
📚🔗 Want more? Discover more Hematology insights: https://focus.wiley.com/topic/amps-su...

This discussion is intended for hematologists, oncologists, cellular therapy specialists, and clinical researchers who want expert commentary on CAR-T therapy, neurotoxicity, and evolving strategies in multiple myeloma care.

#Hematology #ASH #ASH2025 #myelofibrosis #JAKi #CALR #thrombocythemia