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Alavert Television Commercial 2003

Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies.[1][2] In structure, it is closely related to tricyclic antidepressants, such as imipramine, and is distantly related to the atypical antipsychotic quetiapine.[3]

Loratadine was discovered in 1981 and came to market in 1993.[4] It is on the World Health Organization's Model List of Essential Medicines, the most important medications needed in a basic health system.[5] It is available as a generic drug and is marketed for its nonsedating properties. There is a version combined with pseudoephedrine, a decongestant; known as pseudoephedrine/loratadine.