Скачать или смотреть Fixing Your Genes Without DNA: The Epigenetic Reboot

Partial reprogramming is entering human trials. OSK-only pulses can reverse biological age without dedifferentiation, creating the first true epigenetic “youth reset.” CAR-T rejuvenation and gene therapies are advancing as well—but their cost raises an urgent question:

Who gets access to biological repair?

This episode of The Immortality Update explores the scientific breakthrough and the ethical crossroads that arrive with it.

In This Episode We Cover:

• OSK-only partial reprogramming
• Optic-nerve and liver rejuvenation trials
• CAR-T anti-aging immunotherapy
• The cost problem in gene therapy
• AI-designed geroprotectors
• Organ-specific aging clocks
• The emergence of biological inequality
• Why governance now matters as much as science

Longevity science isn’t hypothetical anymore.
Its distribution is the real frontier.

Blog version: https://tomorrowunveiled.com/function...

Rebooting biology demands rebooting ethics.

Chapters:
00:00:00 - Intro
00:00:13 - The Pivotal Shift in Aging Science
00:03:33 - Senolytics Evolving into Vaccines
00:04:17 - Senovax: Vaccinating Against Aged Cells
00:05:42 - Astonishing Preclinical Data
00:06:44 - Senescent Cells and Cancer
00:08:20 - CAR-T Cell Therapy for Aging Gut
00:10:23 - Partial Epigenetic Reprogramming (P-E-R)
00:10:42 - Understanding P-E-R
00:11:28 - Safety Lock: Avoiding Cancer Risk
00:12:08 - Timeline and Human Targets for P-E-R
00:13:26 - Addressing Age-Related Blood Failure
00:15:08 - Precision Medicine with AI
00:15:33 - Generative AI in Drug Discovery
00:17:00 - GLP-1s and Longevity
00:17:17 - GLP-1 Benefits Independent of Weight Loss
00:18:07 - Microdosing GLP-1s
00:18:25 - Ethical and Regulatory Questions
00:19:37 - The Measurement Revolution
00:19:52 - Organ-Specific Proteomic Clocks
00:20:49 - The Muscle Fat Brain Axis
00:20:58 - Structural Biomarkers & Brain Health
00:21:54 - Inflammation Biomarkers in Trials
00:22:49 - The Era of Personalized Maintenance
00:23:04 - Ethical and Practical Questions: Access
00:23:49 - Anti-Aging vs. Geroscience
00:24:21 - Long-Term Unknowns and Safety Watch
00:25:08 - Future is Combinatorial
00:25:41 - Alternative Splicing as Genetic Control
00:26:56 - The Immortality Update