APOE Genetics as a Major Determinant of Alzheimer’s Disease Pathobiology Workshop Day 1

This workshop will bring together investigators who have intensely investigated the effects of APOE on the brain, and the mechanism of Alzheimer’s disease (AD). During the two-day meeting participants will explore the best next steps to develop study approaches that will pinpoint the molecular, genetic, and epigenetic factors necessary for the successful identification of therapeutic approaches. Learn more: https://go.nia.nih.gov/3NMkmLi.

Session 1: APOE genetics (Part 1)
00:46:20 -The APOE4 Story: From Discovery to Diversity, Peggy Pericak-Vance, Ph.D., University of Miami
00:57:00 - Differential APOE effects on gene expression in different human brain cell types, Anthony (Tony) Griswold, Ph.D., University of Miami
2:04:40 - Dissecting APOE biology by CRISPR-based functional genomics, Martin Kampmann, Ph.D., University of California, San Francisco
2:25:35 - South Asians in India (LASI-DAD): Impact of APOE4 with Social Determinants of Health (SDOH), Sharon Kardia, Ph.D., University of Michigan
2:44:35 - A Genetic Modifier of ε4/AD Association and APOE Expression, Lindsay Farrer, Ph.D., Boston University

Session 2: APOE genetics (Part 2)
3:07:20 - Fibronectin 1 and APOE- ε4, Richard Mayeux, M.D., Columbia University
3:30:45 - Interaction of Haptoglobin and APOE in Alzheimer Disease, Jonathan Haines, Ph.D., Case Western Reserve University
4:01:18 - APOE ε2 Allele and Protective Variants in APOE ε4/ε4 Carriers on Alzheimer’s Disease Risk, Gyungah Jun, Ph.D., Boston University
4:19:27 - Rare Protective APOE Variants, Michael Greicius, M.D., MPH., Stanford University

Session 3: Mechanisms of Disease-APOE
4:41:17 - APOE-Genotype Dependent Single-Cell Transcriptomics of Alzheimer's Disease, Li Hui Tsai, Ph.D., Massachusetts Institute of Technology
5:01:34 - The role of APOE genotype in microglial behavior and gene expression, Alison Goate, D.Phil., Mount Sinai
5:19:40 - The role of genetic variants and their influence on the immune response in myeloid cells/microglia, Christopher (Chris) Glass, M.D., Ph.D., University of California, San Diego
5:56:01 - APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia, Michael Haney, Ph.D., University of Pennsylvania
6:13:30 - Biological effects of APOE3ch on amyloid-induced tau seeding/spreading, Yun Chen, Washington University

#APOE #Genetics #AlzheimersDisease