Levodopa + Carbidopa Combination for Parkinsonism

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Video Summary:
Levodopa is used to treat parkinsonism. However when used alone, its effect is very weak. That is because most portion of the drug is degraded in periphery by peripheral dopa decarboxylase. This portion is not available for therapeutic action. Also the dopamine thus produced causes multiple side effects like nausea vomiting and cardiac toxicity. All these issues can be addressed by giving peripheral dopa decarboxylase inhibitor. Carbidopa is one such drug. Inhibition of dopa decarboxylase prevents peripheral conversion of levodopa into dopamine. So larger portion of drug can now enter into the brain for therapeutic action. Also it reduces peripheral side effects.

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.