Скачать или смотреть Diffusion tensor imaging (via MRI) of the heart

Diffusion tensor imaging, also known as DTI, of the murine heart was acquired using MRI at 9.4T. Dataset was acquired by Russell Dibb at the Duke Center for In Vivo Microscopy (CIVM http://www.civm.duhs.duke.edu/). Work done under G. Allan Johnson at CIVM and Chunlei Liu at the Brain Imaging and Analysis Center (BIAC https://www.biac.duke.edu/people/staf....


Dibb, R., Xie, L. & Liu, C. (2014). Magnetic Susceptibility Anisotropy of the Myocardium. In: Proceedings of the 22nd Annual Meeting of ISMRM, Milan, Italy. 2014, p. 627.

Synopsis

The magnetic susceptibility of myocardium is anisotropic and is associated with myocardial organization. We determined the relationship between the magnetic susceptibility and the DTI-based fiber orientation of myocardial tissue. The origins of the observed bulk magnetic susceptibility anisotropy in myocardium can be related to the microscopic anisotropy of peptide bonds in myofibrillar proteins. In MRI, this susceptibility anisotropy is enhanced by the use of contrast agents. Given the high-resolution capability of gradient echo phase, imaging susceptibility anisotropy of the heart would aid in assessing myocardial fiber integrity and alterations induced by cardiac diseases and disorders.