Скачать или смотреть Dosing of Metformin

Stop Under-Dosing Metformin!
Metformin is the gold standard for Type 2 Diabetes, but are we using it to its full potential? A common clinical error is keeping patients on sub-optimal doses (like 500mg OD or BD) and then adding a second drug prematurely.
Here is the correct titration protocol to maximize efficacy:
Start Low: Begin with 500mg OD with the morning meal.
Mitigate Side Effects: Instruct the patient to take it with the first bite of food to reduce GI upset (nausea, diarrhea).
Titrate Up: As tolerance develops, increase gradually:
500mg BD
1000mg morning + 500mg evening
Target: 1000mg BD (2 grams/day).
Why push to 2 grams?
Metformin works by reducing Insulin Resistance.
It has a dose-dependent effect. The optimal therapeutic dose is often 2000mg daily.
It carries almost ZERO risk of hypoglycemia on its own.
Only add a second agent if HbA1c remains uncontrolled after reaching the optimal tolerated dose of Metformin.
What is your experience with Metformin tolerance in your patients? Share in the comments! 👇
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