Скачать или смотреть Mammalian Cell Culture - Raman as a Means of Monitoring & Controlling Upstream Bioprocesses

Mammalian Cell culture technology is now considered a robust technique for the manufacturing of many biotherapeutics including monoclonal antibodies. There are a variety of biotherapeutics that are produced in small-scale to large-scale manufacturing facilities for academic interests,
for clinical studies, or by biopharmaceutical companies for profit. This technology started in 1957, with the development of the stable Chinese Hamster Ovary (CHO) cell lines. Since that time, cell culture has become a focus of Process Analytical Technology (PAT) scientists around the world. In order to make a process robust and increase the yield of the target protein, it takes the careful monitoring of several important analytes and process parameters.

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