How Anthrax Changed Infectious Disease

In this video, Patrick Kelly guides you through the microbiology of anthrax disease before telling the story of Robert Koch, whose research on anthrax helped establish the germ theory of disease, a cornerstone of microbiology. Learn how early discoveries paved the way for modern antibiotics and revolutionized our approach to infectious diseases. Whether you're a microbiology enthusiast or just curious about medical history, this video offers a comprehensive overview of anthrax from its origins to contemporary treatment methods.

☠️NONE OF THE INFORMATION IN THIS VIDEO SHOULD BE USED AS MEDICAL ADVICE OR OPINION. IT IS FOR GENERAL EDUCATION AND ENTERTAINMENT☠️

🔗 L I N K S 🔗
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📜 S O U R C E S 📜
An annotated version of the script can be found here:   / 104362006  
CDC History of Anthrax https://www.cdc.gov/anthrax/basics/an...
Human Anthrax: Update of the Diagnosis and Treatment (2023)
https://www.mdpi.com/2075-4418/13/6/1056
Biostats Anthrax articles https://www.ncbi.nlm.nih.gov/books/NB...
Baylor Anthrax article https://www.bcm.edu/departments/molec...
CDC Anthrax routes https://www.cdc.gov/anthrax/basics/ty...
Ins and Outs of Anthrax Toxin (2016) https://www.ncbi.nlm.nih.gov/pmc/arti...
Anthrax: A Disease and a Weapon (2005) https://citeseerx.ist.psu.edu/documen...

Fournier 1769 book https://www.google.com/books/edition/...
Koch’s Original 1876 paper https://archive.org/details/beitrgezu...
Koch’s 1877 paper with first anthrax images
https://archive.org/details/beitrgezu...
Pouilly le Fort Experiment (FR 1881 / ENG 2002) https://www.ncbi.nlm.nih.gov/pmc/arti...
Robert Koch and the ‘golden age’ of bacteriology (2009) https://www.ijidonline.com/article/S1...
The first live attenuated vaccines (2020) https://www.nature.com/articles/d4285...
Anthrax vaccines at the PI (2024) https://www.mdpi.com/2072-6651/16/2/66
Anthrax and the wool trade (1902) https://www.researchgate.net/publicat...
John Henry Bell (2002) https://www.ncbi.nlm.nih.gov/pmc/arti...
Brachman Vaccine Paper (1962) https://www.ncbi.nlm.nih.gov/pmc/arti...

Combinations of Monoclonal Antibodies to Anthrax Toxin (2013) https://www.ncbi.nlm.nih.gov/pmc/arti...
Raxibacumab approval from FDA https://www.accessdata.fda.gov/drugsa...
Obiltoxaximab (2016) https://pubmed.ncbi.nlm.nih.gov/27085...
Anthim (obiltoxiaximab) https://anthim.com/what-is-anthim.html
Antibodies against Anthrax Toxins (2022) https://www.mdpi.com/2072-6651/14/3/172

💻 C O N T A C T 💻
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⌛T I M E S T A M P S ⌛
0:00 intro
0:57 Microbiology of Anthrax Disease
4:27 Early History of Anthrax
6:28 Nicolas Fournier
8:15 Davaine and Rayer find bacillus anthracis
10:10 Robert Koch's work on anthrax
18:37 Modern treatments for anthrax

14:56 Louis Pasteur, Pouilley-le-Fort, and the anthrax vaccine
#historyofmedicine #medicalhistory