The Council of Ephesus and the deification of Mary as 'Theotokos'. The Qur'an responds.

The Council of Ephesus was a council of Christian bishops convened in Ephesus (near present-day Selçuk in Turkey) in AD 431 by the Roman Emperor Theodosius II. This third ecumenical council condemned the teachings of Nestorius, Patriarch of Constantinople, who held that the Virgin Mary may be called the Christotokos, "Christ-bearer" but not the Theotokos, "God-bearer".

The Second Vatican Council in 1964 referred to Mary as 'Queen of the Universe'.

The increasing exultation of Mary led the Qur'an to condemn these excesses in the Christian religion:

And on Judgment Day God will say, “O Jesus, son of Mary! Did you ever ask the people to worship you and your mother as gods besides Allah?” He will answer, “Glory be to You! How could I ever say what I had no right to say? If I had said such a thing, you would have certainly known it. You know what is hidden within me, but I do not know what is within You. Indeed, You alone are the Knower of all unseen. [Qur'an 5:116]

O People of the Book! Commit no excesses in your religion: nor say of Allah aught but the truth. Christ Jesus the son of Mary was (no more than) a messenger from Allah, and His Word, which He bestowed on Mary, and a spirit proceeding from Him: so believe in Allah and His Messengers. Say not "Three": desist: It will be better for you: For Allah is One God: Glory be to Him: (Far Exalted is He) above having a son. To Him belong all things in the heavens and on earth. And enough is Allah as a Disposer of affairs. [Qur'an 4:171]