Enhanced benefits of the AHA Life's Essential 8 in APOE 4 carriers

Santiago Clocchiatti-Tuozzo, MD, Yale School of Medicine, New Haven, CT, shares his work investigating the impact of APOEε4 carrier status on the benefits of adhering to the American Heart Association's Life’s Essential 8 (LE8) guidelines in reducing cardiovascular disease risk. Using UK Biobank data, they analyzed 317,174 participants, finding that APOEε4 carriers experienced an 11% greater reduction in stroke, transient ischemic attack, or myocardial infarction risk with LE8 optimization compared to non-carriers. Among all participants, each 1 SD increase in LE8 score correlated with a 28% risk reduction for these events. A significant interaction between APOEε4 status and LE8 score was observed, indicating enhanced benefits for carriers. These findings underscore the importance of educating APOE ε4 carriers, particularly middle-aged individuals without prior vascular events, about strategies for improving long-term neuro- and cardiovascular health. This interview took place during the International Stroke Conference 2024 in Phoenix, AZ.

These works are owned by Magdalen Medical Publishing (MMP) and are protected by copyright laws and treaties around the world. All rights are reserved.