Phosphatidic acid; formation, breakdown and Functions to the body

Phosphatidic acid (PA) is an anionic phospholipid that plays a crucial role in cell signaling and direct activation of lipid-gated ion channels. It is a precursor for the biosynthesis of many other lipids and acts as a biosynthetic precursor for the formation of all acylglycerol lipids in the cell 1. PA can be formed in three ways: by phospholipase D (PLD), via the hydrolysis of the P-O bond of phosphatidylcholine (PC) to produce PA and choline; by the phosphorylation of diacylglycerol (DAG) by DAG kinase (DAGK); or by the acylation of lysophosphatidic acid by lysoPA-acyltransferase (LPAAT). PA can be converted into DAG by lipid phosphate phosphohydrolases (LPPs) or into lyso-PA by phospholipase A (PLA).

PA has emerged as a promising muscle-building supplement, but research is still underway to determine its effectiveness.

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