Скачать или смотреть Rethinking of Aging. Part 5. Dr. Greg Fahy Trials. Rejuvenation or Accelerated Aging?

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A clinical trial led by Dr. Greg Fahy in 2019 suggested that daily growth hormone (GH) injections combined with supplements (zinc, selenium, metformin, DHEA, and vitamin B3) may reverse biological (epigenetic) age by approximately 2.5 years and stimulate thymus regrowth. This result was corroborated in studies conducted in 2023 and 2024. Additionally, participants experienced improved blood lymphocyte counts, reduced body fat, lower resting heart rates, and increased lean body mass. However, after stopping treatment, epigenetic aging indicators returned to pre-trial levels within three years, raising questions about the permanence of these effects. Dr. Fahy’s regimen has generated both excitement and skepticism, with concerns over potential adverse effects, such as arterial stiffness indicated by reduced diastolic blood pressure and possible autoimmune issues related to increased lymphocyte counts. Some critics argue these factors may point more toward accelerated aging than rejuvenation.

Dr. Fahy also promotes a Mediterranean-style diet, emphasizing plant-based foods and avoiding fast-digesting carbohydrates, though the regimen itself remains controversial. In 2021, the rejuvenation procedure became available commercially in the US and UK, raising further concerns about its marketing. The use of GH to increase muscle mass is debated, with limited clinical evidence supporting strength improvement from short-term GH therapy. Dr. Fahy claims that combining DHEA, metformin, and GH is necessary for epigenetic age reversal, but some suggest his emphasis on epigenetic age clocks might not fully correlate with functional markers of rejuvenation. Instead, metrics like blood pressure, heart rate variability, and lung capacity (FLC) may better reflect age-related physical function.

Alternative approaches also exist, such as supplementation with β-Hydroxy β-methylbutyric acid (HMB), which showed better results in muscle growth and endurance on a carnivore diet than GH did. Additionally, Dr. Edward Omron’s trial of metformin and NAM without intense exercise or dietary changes led to weight loss and health improvements, although metformin carries side effects that may interfere with muscle strength and testosterone levels. Berberine (BBR), a potential alternative to metformin, demonstrates promising anticancer and metabolic effects through its influence on gut microbiota and cellular aging processes. BBR’s anticancer properties, which include promoting beneficial gut bacteria and reducing senescence, show potential for aging and disease prevention.

Exercise and diet have also shown promise in stimulating natural DHEA and GH production. Regular physical activity, particularly aerobic and resistance exercises, and calorie restriction can mitigate the age-related decline in DHEA. DHEA supplementation has benefits for blood vessel health, potentially reducing arterial stiffness, while GH and other hormone natural secretions benefit from deep sleep, fasting, and specific amino acids like arginine, glycine, and lysine. The author of this presentation experiences increased lung capacity, reduced pulse pressure, and slower resting heart rate (RHR), and he believes that these are true signs of successful functional rejuvenation. However, the development of protocols targeting skin and hair rejuvenation to complement systemic anti-aging efforts is necessary.