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Van Vreeswijk Theoretical Neuroscience Seminar
www.wwtns.online; on twitter: WWTNS@TheoreticalWide
Wednesday, April 19, 2023, at 11:00 am ET
Eric Shea-Brown
University of Washington
Seattle

Title: Assigning credit through the "other” connectome

Abstract: Learning in neural networks requires assigning the right values to thousands to trillions or more of individual connections, so that the network as a whole produces the desired behavior. Neuroscientists have gained insights into this “credit assignment” problem through decades of experimental, modeling, and theoretical studies. This has suggested key roles for synaptic eligibility traces and top-down feedback signals, among other factors. Here we study the potential contribution of another type of signaling that is being revealed in greater and greater fidelity by ongoing molecular and genomics studies. This is the set of modulatory pathways local to a given circuit, which form an intriguing second type of connectome overlayed on top of synaptic connectivity. We will share ongoing modeling and theoretical work that explores the possible roles of this local modulatory connectome in network learning.