Isoniazid (inh) - A narrow spectrum antibiotic for tuberculosis

Описание к видео Isoniazid (inh) - A narrow spectrum antibiotic for tuberculosis

Isoniazid (INH) is a narrow spectrum antibiotic used in the treatment of tuberculosis. This drug is a nicotinic acid derivative with hydrazide as functional group.

Isoniazid is a prodrug that is activated within the mycobacterial cell by one of the important enzyme catalase-peroxidase in presence of hydrogen peroxide. This enzyme is coded by the gene Kat G which can be mutated by the organism to produce resistance.

Finally this drug forms an adduct with NADH molecules which inhibits synthesis of mycolic acid within the mycobacteria.

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