Biology of DSDs (7) 5-alpha reductase deficiency

5-alpha reductase deficiency, also known as 5-ARD, is a sex development condition which affects individuals with a 46,XY karyotype. Those with 5-ARD develop internal testes and a Wolffian structure, but a lack of dihydrotestosterone (DHT)--the sex hormone solely responsible for the development of male external genitalia in the womb--often causes the fetus to develop external genitalia that looks female-typical.

If you want to help improve medical research and psychological support for individuals with these conditions, you can donate to DSDFamilies.
(https://dsdfamilies.org/donate).

Biology of DSDs playlist:
   • Biology of Sex Development Disorders  

Transcripts, sources, and membership at:
https://www.theparadoxinstitute.com/p...

References and additional reading:
[1] NIH. (2020). 5-alpha reductase deficiency. Genetics Home Reference, National Library of Medicine.
[2] Isfort, A. (2016). 5-alpha reductase deficiency. Medscape.
[3] LOCAH. (2018). The intersex masterpost. Medium.
[4] Cheon, CK. (2011). Practical approach to steroid 5-ARD type 2 deficiency. Eur J Pediatr, 170(1).
[5] Kumar, G., Meca-Barboza, J. (2020). 5 Alpha Reductase Deficiency. StatPearls Publishing.
[6] Randall, V. (1994). Role of 5-ARD in health and disease. B Clinical Endocrinology & Metabolism, 8(2).

Support groups and foundations:
AccordAlliance.org