Advanced Organic Chemistry: Acids and Bases

In this installment of the Synthesis Workshop Advanced Organic Chemistry course, Emily Wearing (Schindler group, University of Michigan) joins us to give a talk on acids and bases.

References (in order of appearance):
Wade, L.G.; Simek, J.W. Organic Chemistry 9th Ed. Pearson, 2016.
Eğe, S. Organic Chemistry Structure and Reactivity 5th Ed. Hayden-McNeil, 2018.
Flow chart adapted from course lecture from Professor Palandoken, Cal Poly, SLO, 2016.
pKas: Ripin, D.H.; Evans, D.A. pKa Table. Wade, L.G.; Simek, J.W. Organic Chemistry 9th Ed. Pearson, 2016. Carey, F.A.; Sundberg, R.J. Advanced Organic Chemistry A: Structure and Mechanisms, Springer, 2007.
J. Org. Chem. 1994, 59, 6456-6458. Ripin, D.H.; Evans, D.A. pKa Table.
J. Am. Chem. Soc. 1984, 106, 22, 6759-6767. Gazz. Chim. Ital. 1987, 117, 237-243. J. Am. Chem. Soc. 1987, 109, 809-812. J. Org. Chem. 1994, 59, 6456-6458.
pKas: Ripin, D.H.; Evans, D.A. pKa Table.; Liebigs Ann. 1996, 1055-1081.; Tet. Lett. 2018, 59, 3738-3748.; Eur. J. Org. Chem. 2019, 6735-6748.
Loudon, M.; Parise, J. Organic Chemistry 7th Ed. W. H. Freeman, 2021.
J. Am. Chem. Soc. 1963, 85, 3533-3539. Chem. Rev. 1975, 75, 1-20. Carey, F.A.; Sundberg, R.J. Advanced Organic Chemistry A: Structure and Mechanisms, Springer, 2007.
Chem. Rev. 1975, 75, 1-20. Carey, F.A.; Sundberg, R.J. Advanced Organic Chemistry A: Structure and Mechanisms, Springer, 2007.
J. Am. Chem. Soc. 1955, 77, 6269-6280. Angew. Chem. Int. Ed. 2011, 50, 6470-6505.
Smith, M.B.; March, J. March’s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 7th Ed. Wiley, 2013. Science, 1979, 206, 13-20.
Liebigs Ann. 1996, 1055-1081.