Скачать или смотреть Central Dogma for the MCAT: Transcription, Translation & Gene Regulation I Jack Westin MCAT Podcast

DNA doesn’t “do", it instructs. In this episode of the Jack Westin MCAT Podcast, Mike and Molly walk through the central dogma, how we go from DNA → RNA → protein—and the regulation that makes different cells, well, different. Perfect for MCAT Bio/Biochem: we hit transcription, RNA processing, translation mechanics (A–P–E sites), start/stop codons, eukaryote vs. prokaryote differences, and multi-layered gene expression regulation (chromatin, transcription factors, miRNA/siRNA, ubiquitin, & more).

🔑 What you’ll learn
Central dogma overview (DNA → RNA → protein)
Transcription: promoter, template vs. coding strand, initiation/elongation/termination
Eukaryotic RNA processing: 5′ cap, splicing (introns vs. exons, alternative splicing), poly-A tail
Translation: AUG start (Met), codons/anticodons, tRNA charging, ribosome A–P–E sites, stop codons (UAA/UAG/UGA)
Eukaryotes vs. Prokaryotes: 40/60/80S vs. 30/50/70S ribosomes, coupled transcription–translation, operons (lac/trp)
Regulation: heterochromatin vs. euchromatin, histone acetylation, DNA methylation, transcription factors, miRNA/siRNA silencing, post-translational mods (ubiquitin, phosphorylation)

00:00 Intro & last episode recap (Mendelian inheritance)
01:15 Central Dogma: why DNA is a blueprint, not the product
03:40 DNA basics: anti-parallel double helix, histones
06:25 Transcription (initiation → elongation → termination)
12:30 Eukaryotic RNA processing: 5′ cap, splicing, poly-A tail
18:40 Translation setup: mRNA, tRNA, rRNA, ribosome subunits
22:10 Reading frames, AUG start, A–P–E sites in action
28:35 Stop codons (UAA, UAG, UGA) & peptide release
31:10 Prokaryotes vs. eukaryotes: 70S vs. 80S, coupling, operons
36:20 Gene expression regulation: chromatin state, acetylation/methylation
41:10 Transcription factors & promoter control; lac/trp operons
45:40 Post-transcriptional & post-translational control (miRNA, ubiquitin)
49:10 MCAT strategy tips & common traps
51:00 Next episode teaser: replication, cell cycle, mutations & cancer

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