Скачать или смотреть When Inhibitory Neurons are Reduced and Reused

Alex Pollen, a professor at UCSF and a member of the Kavli Institute for Fundamental Neuroscience, and graduate student Matthew Schmitz explain their recent study revealing the evolutionary elegance of inhibitory neuron development across mammalian species.

They analyzed individual inhibitory neurons during early primate brain development, and developed a taxonomy of neuron classes from this data, spanning developmental time.

Interneuron classes in mouse and primate are mostly similar, but with some interesting examples that show how cell types can be “reduced or reused” in different species: A new class of dopaminergic neurons form a wreath shape around the striatum of the primate brain, that aren’t seen in mouse brain (reduced). And a neuron class in the olfactory bulb of mice has a ‘related’ class that migrates via a previously unknown route to the prefrontal cortex in primate (reused).

https://www.nature.com/articles/s4158...

Special thanks to the Kavli Institute for Fundamental Neuroscience, UC San Franciscio, and the Pollen Lab.