Скачать или смотреть CPTR Workshop 2016 Day 4: Sebastien Gagneux

Sebastien Gagneaux reminded participants that knowledge of how bacteria evolve and acquire resistance to new drugs will be critical to protecting newly developed TB therapies. Gagneaux relayed the case study of a Tibetan refugee in Switzerland who had primary resistance to seven TB drugs and who then developed resistance to bedaquiline and delamanid when exposed. Though best practices were not followed in this case, the anecdote served as a reminder of how fragile new tools can be, and that realties on the ground are not always perfectly in line with best practices. Gagneaux also presented interesting research on the effect of mutations on the fitness of TB strains. While dogma suggests that the more mutations, the less fit the strain becomes, the data suggested that this relationship is not constant, and highlighted that more research is needed on the disease, and its relationship with the host and between hosts (transmission).