What if some of the most popular supplements you trust are actually working against your mitochondria after age 50? In this video, Dr. David Sinclair explains the science-backed reason why certain vitamins, antioxidants, and hormone-boosting supplements may backfire as we age—and how they can silently interfere with mitochondrial renewal, cellular repair, and longevity pathways.
As we get older, the goal is no longer to overstimulate the body, but to restore mitochondrial function and activate longevity genes like AMPK, sirtuins, and autophagy. Backed by real scientific evidence, this episode breaks down which supplements may blunt these signals, why timing and dosage matter, and what actually helps your body make new mitochondria naturally.
You’ll learn how aging changes supplement response, why “more” is often worse after 50, and how mitochondrial biogenesis really works. This is not anti-supplement—this is precision longevity science.
If you care about energy, metabolism, brain health, muscle preservation, and living longer with fewer diseases, this is essential viewing.
Watch till the end to understand how to support mitochondrial renewal the RIGHT way—based on science, not marketing.
⏱️ TIMESTAMPS:
00:00 – Why supplements stop working the same after 50
01:42 – The real role of mitochondria in aging
03:18 – Why antioxidants can block mitochondrial growth
05:04 – Supplements that interfere with longevity genes
06:55 – AMPK, sirtuins, and cellular repair explained
08:31 – Why growth signals accelerate aging
10:07 – The supplement myth most people believe
11:48 – How to actually make new mitochondria
13:26 – Fasting, stress, and mitochondrial biogenesis
15:02 – What long-lived populations do differently
16:41 – Smarter supplement strategy after 50
18:12 – Final longevity takeaway
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