Idiopathic inflammatory myopathies: diagnosis and treatment

Об этом видео:Idiopathic inflammatory myopathies (IIM) are a group of chronic, autoimmune conditions affecting primarily the proximal muscles. The most common types are dermatomyositis, polymyositis, necrotizing autoimmune myopathy, and sporadic inclusion body myositis. Patients typically present with sub-acute to chronic onset of proximal weakness manifested by difficulty with rising from a chair, climbing stairs, lifting objects, and combing hair. Laboratory investigations, including increased serum creatine kinase and myositis specific antibodies may help in differentiating clinical phenotype and to confirm the diagnosis. However, muscle biopsy remains the gold standard for diagnosis.
Additionally to that, the first evidence-based guidelines in this field, which has been developed by a working group of the British Society for Rheumatology, recommend all IIM patients should be screened for swallowing difficulties. The guidelines also recommend that adult patients be screened for interstitial lung disease, fracture risk, and cancer that may be associated with IIM.
These disorders are potentially treatable with proper diagnosis and initiation of therapy. Goals of treatment are to eliminate inflammation, restore muscle performance, reduce morbidity, and improve quality of life. The named guideline of the British Society for Rheumatology include the use of glucocorticoids to reduce muscle inflammation and conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) for long-term treatment (methotrexate, leflunomide, and sulfasalazine), possibly rituximab, abatacept and other biological disease-modifying antirheumatic drugs (bDMARDs). Who is armed is protected, take care of yourself and be healthy.