Diuretics - Carbonic Anhydrase Inhibitors - Acetazolamide - Pharmacology Series

Carbonic Anhydrase Inhibitors - Acetazolamide - Pharmacology Series - The proximal convoluted tubule (PCT) of the kidney - Carbonic anhydrase enzyme, Le Chatelier principle, Carbon Dioxide.

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►👨‍🏫💊Antibiotics Lectures: https://www.medicosisperfectionalis.c... ... Check out my brand new "Electrolytes" course at https://www.medicosisperfectionalis.c... and use the PROMO code: ELECTROLYTES50 to get a 50% discount. The proximal convoluted tubule (PCT) is very active, it reabsorbs 65 % of sodium as well as many other electrolytes. We have talked about the normal physiology of the proximal convoluted tubule in a previous video.

Carbonic anhydrase is an enzyme in the proximal convoluted tubule that helps dissociate the carbonic acid (H2CO3) into protons (H+) and bicarbonate (HCO3-). Then, the H+ will be secreted in urine while the HCO3- will be reabsorbed into the blood..

Carbonic anhydrase inhibitors (e.g. acetazolamide) will inhibit the previous step leading to loss of bicarbonate in the urine (alkalinization of urine) and reabsorption of protons into blood (acidification of blood leading to metabolic acidosis).

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