Скачать или смотреть Genetic Testing Identifies MTHFR Gene Mutation’s Role in Affecting Anxiety, Depression, and ADHD.

This video explains how the physiology and genetic processes behind the MTHFR (methylenetetrehydrofolste reductase) gene mutation is crucial to understanding the influence the MTHFR gene has on mental health.

Visit ‪@DanPurserMD‬ website and page for genetic testing and MTHFR info.

Disclaimer:

I am not a licensed physician and cannot offer professional medical advice. This is for education and discussion purposes only as a student.

Resources:

Berk, M., Ng, F., Dean, O., Dodd, S., & Bush, A. I. (2008). Glutathione: a novel treatment target in psychiatry. Trends in
Pharmacological Sciences, 29(7), 346–351. https://doi.org/10.1016/j.tips.2008.05.001

Bjelland, I., Tell, G. S., Vollset, S. E., Refsum, H., & Ueland, P. M. (2003b). Folate, Vitamin B12, Homocysteine, and the MTHFR
677C→T Polymorphism in Anxiety and Depression. Archives of General Psychiatry, 60(6), 618.
https://doi.org/10.1001/archpsyc.60.6.618

Mech, A. W., & Farah, A. (2016). Correlation of Clinical Response With Homocysteine Reduction During Therapy With Reduced B
Vitamins in Patients With MDD Who Are Positive for MTHFR C677T or A1298C Polymorphism. The Journal of Clinical
Psychiatry, 77(05), 668–671. https://doi.org/10.4088/jcp.15m10166

Wu, Y.-L., Ding, X.-X., Sun, Y.-H., Yang, H.-Y., Chen, J., Zhao, X., Jiang, Y.-H., Lv, X.-L., & Wu, Z.-Q. (2013). Association between
MTHFR C677T polymorphism and depression: An updated meta-analysis of 26 studies. Progress in
Neuro-Psychopharmacology and Biological Psychiatry, 46, 78–85. https://doi.org/10.1016/j.pnpbp.2013.06.01

Araszkiewicz, A. F., Krzysztof Jańczak, Paweł Wójcik, Bartłomiej Białecki, Kubiak, S., Szczechowski, M., & Januszkiewicz-Lewandowska, D. (2025). MTHFR Gene Polymorphisms: A Single
Gene with Wide-Ranging Clinical Implications—A Review. Genes, 16(4), 441–441. https://doi.org/10.3390/genes16040441

Gilbody, S., Lewis, S., & Lightfoot, T. (2006). Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review. American Journal of
Epidemiology, 165(1), 1–13. https://doi.org/10.1093/aje/kwj347

Leclerc, D., Sibani, S., & Rozen, R. (2013). Molecular Biology of
Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms. In www.ncbi.nlm.nih.gov.
Landes Bioscience. https://www.ncbi.nlm.nih.gov/books/NBK6561/

Moll, S., & Varga, E. A. (2015). Homocysteine and MTHFR Mutations. Circulation, 132(1). https://doi.org/10.1161/circulationaha.114...

Wan, L., Li, Y., Zhang, Z., Sun, Z., He, Y., & Li, R. (2018). Methylenetetrahydrofolate reductase and psychiatric diseases. Translational Psychiatry, 8(1).
https://doi.org/10.1038/s41398-018-0276-6

Zhang, Y.-X., Yang, L.-P., Gai, C., Cheng, C.-C., Guo, Z., Sun, H.-M., & Hu, D. (2022). Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis. Frontiers in