Скачать или смотреть Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca | Huberman Lab

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Dr. Sergiu Pașca discusses autism as a complex spectrum disorder defined behaviorally and influenced by diverse genetic and environmental factors. He highlights gender differences in diagnosis, the challenges of correlating behavioral features with biological markers, and the limitations of current treatments, which largely focus on symptom management. Advances in genetics reveal many autism-associated genes, while emerging therapies like gene editing and stem cell approaches offer future hope, particularly for rare genetic subtypes. Central to his work is the use of induced pluripotent stem cells (iPSCs) to model human brain development via 3D organoids and assemblids that replicate brain circuits. Transplanting these organoids into animal models bridges in vitro and in vivo research, enabling better study of human neurons and potential therapies. Ethical considerations surrounding brain organoid research are actively addressed. His research has advanced understanding of monogenic neurodevelopmental disorders and aims to expand therapeutic options for severe autism and other brain diseases, underscoring the transformative potential of combining stem cell biology, genetics, and neurotechnology.

00:00 Introduction
01:06 Gender Differences and Diagnostic Challenges in Autism
02:06 Biological Basis, Early Diagnosis, and Behavioral Features
02:59 The Role of Genetics and Environmental Factors
03:56 Current Treatment Paradigms for Autism
04:43 The Promise and Challenges of Gene Therapy
05:37 Stem Cells and Modeling Human Brain Development
06:31 Organoids and Assemblids
07:35 Transplantation of Organoids into Animal Models
08:25 Ethical Considerations in Brain Organoids and Assemblids
09:14 Application to Neurodevelopmental and Psychiatric Disorders
10:07 Future Perspectives, and Scientific Culture

This video is a podcast summary of the Huberman Lab episode titled 'Using Stem Cells to Cure Autism, Epilepsy & Schizophrenia | Dr. Sergiu Pașca'.

Link:    • Curing Autism, Epilepsy & Schizophrenia wi...  
Publish date: Aug 18, 2025

Summary article: https://podmarized.com/episodes/huber...

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