JCS 30. “Cell - in - cell” structures: Polyploid giant cancer cells

Описание к видео JCS 30. “Cell - in - cell” structures: Polyploid giant cancer cells

"Cell-in-cell" structures, where one cell engulfs another, are significant in cancer biology, particularly in relation to polyploid giant cancer cells (PGCCs). PGCCs are large, multi-chromosome cancer cells that play key roles in tumor progression, metastasis, and therapy resistance.

These structures often arise through a process called entosis, where one cell invades another. PGCCs contribute to tumor heterogeneity and adaptability, helping tumors survive harsh conditions and resist treatments. Their presence is linked to poor prognosis and highlights the need for targeted cancer therapies to address these resilient cells.

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