AntiFolate Antibiotics||Indirect DNA Synthesis Inhibitors||Antimicrobial agent(AMA)

Описание к видео AntiFolate Antibiotics||Indirect DNA Synthesis Inhibitors||Antimicrobial agent(AMA)

Topical Sulfonamide:
●Sulfacetamide-Rx of Bacterial Conjunctivitis & Trachoma (Eye drops)
●Silver Sulfadiazine(more thanMafenide)-Doc for Burn px
S/E: Mafenide being CA inhibitors causes metabolic acidosis(by getting absorbed from skin)
Mafenide causes Allergy and pain on site of application.
Note:
•All antifolate C/I in Neonates & 3rd Trimester of Pregnancy.
•All DHFRase inhibitors causes Megaloblastic anemia.-Add Leucovorin/Folinic acid 10 mg/day to prevent it.
•DHFRase Inhibitors in human is?........Methotrexate(Anticancertherapy)

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